Surgical Outcome of Pulmonary Metastasectomy for Hepatocellular Carcinoma Recurrence in Liver Transplant Patients.

Content Provider	Europe PMC
Author	Jeong, Yong Ho Hwang, Shin Lee, Geun Dong Choi, Se Hoon Kim, Hyeong Ryul Kim, Yong-Hee Park, Seung-Il Kim, Dong Kwan
Copyright Year	2021
Abstract	BackgroundRecurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) results in poor survival outcome. This study assessed the clinical outcomes of pulmonary metastasectomy in LT recipients with pulmonary metastasis of HCC in a high-volume transplant center and analyzed factors prognostic of survival following metastasectomy.Material/MethodsThis study analyzed outcomes in 52 patients who underwent pulmonary resection due to pulmonary metastasis as the first recurrence of HCC after LT from January 2004 to December 2017 in a single center.ResultsThe 52 enrolled patients included 46 men and 6 women, aged 56.0±6.6 years. Their 1-, 3-, and 5-year survival rates after pulmonary resection were 75.0%, 43.5%, and 33.9%, respectively. The 1-, 3-, and 5-year survival rates were 85.3%, 47.1%, and 34.2%, respectively, in patients with further metastases and 55.6%, 38.1%, and 38.1%, respectively, in patients without further metastases (P=0.45). The size and number of pulmonary metastatic nodules were unrelated to survival rates (all P>0.10). A shorter recurrence-free period after LT (hazard ratio [HR]=0.553, P=0.006), elevated alpha-fetoprotein concentration at metastasectomy (HR=2.142, P=0.03), and adjuvant chemotherapy after metastasectomy (HR=3.79, P=0.003) were independent risk factors for survival after metastasectomy.ConclusionsPulmonary metastasectomy for HCC recurrence in LT recipients showed favorable survival outcomes. Independent risk factors for survival after metastasectomy included recurrence-free survival after LT, alpha-fetoprotein level at metastasectomy, and adjuvant chemotherapy after metastasectomy.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8122851&blobtype=pdf
ISSN	14259524
Journal	Annals of Transplantation [Ann Transplant]
Volume Number	26
PubMed Central reference number	PMC8122851
PubMed reference number	33972494
e-ISSN	23290358
DOI	10.12659/aot.930383
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2021-05-11
Access Restriction	Open
Rights License	This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) © Ann Transplant, 2021
Subject Keyword	Carcinoma, Hepatocellular Liver Transplantation Metastasectomy Lung Neoplasms
Content Type	Text
Resource Type	Article
Subject	Transplantation