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Post-mortem persistence of SARS-CoV-2: a preliminary study.
| Content Provider | Europe PMC |
|---|---|
| Author | Sablone, Sara Solarino, Biagio Ferorelli, Davide Benevento, Marcello Chironna, Maria Loconsole, Daniela Sallustio, Anna Dell’Erba, Alessandro Introna, Francesco |
| Abstract | Since the beginning of March 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been the cause of millions of deaths worldwide. The need to better define the pathogenesis of coronavirus disease 19 (Covid-19) as well as to provide the correct statistical records concerning deaths related to this virus, inevitably involves the role of forensic pathology and routine autopsy practice. Currently, some data on macroscopic and microscopic features in autopsies performed in suspected Covid-19 cases are reported in the literature. The persistence of SARS-CoV-2 in cadavers has not yet been elucidated and only a few reports have emphasized the importance of evaluating the Virus RNA in post-mortem tissues. In this preliminary study, we observed that SARS-CoV-2 survives in multiple cadaver tissues many days after death despite some extreme conditions of post-mortem body preservation. The results of this on-going analysis could help improve the safety of working practices for pathologists as well as understanding the possible interaction between microbiological agents and the cadaver tissue’s supravital reactions. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8105695&blobtype=pdf |
| ISSN | 1547769X |
| Journal | Forensic Science, Medicine, and Pathology [Forensic Sci Med Pathol] |
| Volume Number | 17 |
| DOI | 10.1007/s12024-021-00375-z |
| PubMed Central reference number | PMC8105695 |
| Issue Number | 3 |
| PubMed reference number | 33963967 |
| e-ISSN | 15562891 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2021-05-08 |
| Publisher Place | New York |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021 |
| Subject Keyword | SARS-CoV-2 Viral RNA Cadaver tissue samples Post-mortem interval COVID-19 autopsy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine |
