Mechanisms of Action of the PGLYRP1/Tag7 Protein in Innate and Acquired Immunity.

Content Provider	Europe PMC
Author	Yashin, D. V. Sashchenko, L. P. Georgiev, G. P.
Copyright Year	2021
Abstract	One of the promising fields of modern molecular biology is the search for newproteins that regulate the various stages of the immune response and theinvestigation of the molecular mechanisms of action of these proteins. Suchproteins include the multifunctional protein PGLYRP1/Tag7, belonging to thePGRP-S protein family, whose gene was discovered in mice at the Institute ofGene Biology, Russian Academy of Sciences, in 1996. PGLYRP1/Tag7 is classifiedas a protein of innate immunity; however, it can also participate in theregulation of acquired immunity mechanisms. In this paper, we consider theinvolvement of PGLYRP1/Tag7 in the triggering of antimicrobial defensemechanisms and formation of subsets of cytotoxic lymphocytes that kill tumorcells. The paper emphasizes that the multifaceted functional activity of Tag7in the immune response has to do with its ability to interact with variousproteins to form stable protein complexes. Hsp70-associated Tag7 can induce thedeath of tumor cells carrying the TNFR1 receptor. Tag7, associated with theMts1 (S100A4) protein, can stimulate the migration of innate and adaptiveimmune cytotoxic lymphocytes to a lesion site. Involvement of Tag7 in theregulation of immunological processes suggests that it may be considered as apromising agent in cancer therapy. These properties of Tag7 were used todevelop autologous vaccines that have passed the first and second phases ofclinical trials in patients with end-stage melanoma and renal cancer. TheC-terminal peptide of Tag7, isolated by limited proteolysis, was shown toprotect the cartilage and bone tissue of the ankle joint in mice with inducedautoimmune arthritis and may be a promising drug for suppressing thedevelopment of inflammatory processes.
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ISSN	20758251
Journal	Acta Naturae
Volume Number	13
DOI	10.32607/actanaturae.11102
PubMed Central reference number	PMC8084298
Issue Number	1
PubMed reference number	33959389
Language	English
Publisher	A.I. Gordeyev
Publisher Date	2021-01-01
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of theCreative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original work isproperly cited. Copyright ® 2021 National Research University Higher School of Economics.
Subject Keyword	PGLYRP1/Tag7 cytotoxicity antimicrobial effect antitumor therapy Mts1 Hsp70 HspBP1 TNFR1
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry Molecular Medicine Biotechnology