P53 staining index and zonal staining patterns in actinic keratoses.

Content Provider	Europe PMC
Author	Javor, Sanja Gasparini, Giulia Biatta, Chiara Maria Cozzani, Emanuele Cabiddu, Francesco Ravetti, Jean Louis Vellone, Valerio Gaetano Parodi, Aurora
Abstract	Actinic keratoses (AKs) are common dysplastic lesions resulting from chronic excessive ultraviolet exposure. Neither the clinical grade of thickness nor the histological grade of dysplasia seems valid predictors of aggressive potential of AKs. Instead, the mutational status in AKs appears to predict well the clinical course. TP53 gene mutations result in a non-functional protein resistant to degradation, thus immunohistochemical staining for p53 can suggest mutation status. Increased p53 was associated with progression from AK to squamous cell carcinoma. To investigate how the intensity of p53 staining (p53 staining index) varies according to body site, histological subtype and grade dysplasia of AKs. Secondly, we sought to investigate the distribution in the epidermal layers of non-functional p53 (zonal staining patterns). p53 staining index was greater than 50% in 90.7% of AKs. p53 staining index was significantly higher in older age (p < 0.0093) and in facial AKs compared to other body areas (p = 0.03). A significant correlation between p53 staining index and grade of dysplasia was observed (p = 0.006) and between p53 staining index and zonal p53 staining pattern (p = 0.003). No significant differences in p53 staining index among the various histological AK types were observed. No correlation between clinical and histological grade. All AKs, independently from their clinical appearance, should be treated but special attention is required for AKs on severely photodamaged skin on the face and in older patients.
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ISSN	03403696
Journal	Archives of Dermatological Research [Arch Dermatol Res]
Volume Number	313
DOI	10.1007/s00403-020-02104-y
PubMed Central reference number	PMC8043885
Issue Number	4
PubMed reference number	32642809
e-ISSN	1432069X
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2020-07-08
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020
Subject Keyword	Actinic keratosis p53 Squamous cell carcinoma Immunohistochemistry Non-melanoma skin cancer
Content Type	Text
Resource Type	Article
Subject	Dermatology