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Efficient combination of Human Papillomavirus Genotyping for the triage of women with Atypical Squamous Cells of Undetermined Significance in Chinese rural population: A population-based study.
| Content Provider | Europe PMC |
|---|---|
| Author | Wang, Wei Zhang, Huina Lin, Leqian Yang, Aimin Yang, Jing Zhao, Weihong Wang, Zhilian Zhang, Lili Su, Xiaoqiang Wang, Zhe Wang, Chen Zhang, Haitao Feng, Bo Li, Dongyan Liu, Huiqiang Niu, Xiaofen Wang, Jintao Song, Jinghui Li, Li Lv, Weiguo Zhao, Chengquan Hao, Min |
| Copyright Year | 2021 |
| Abstract | Objective: In this prospective, population-based study, we evaluated the utility of high-risk human papillomavirus (HR-HPV) genotyping for triaging women with atypical squamous cells of undetermined significance (ASC-US) in the Chinese rural area.Methods: A total of 40,000 women were recruited from rural areas of Shanxi Province, China, between June 2014 and December 2014. Women with Pap results of ASC-US underwent HPV genotyping, colposcopy and histopathological examination. For those with normal cervixes or cervical intraepithelial neoplasia (CIN) 1 on the initial evaluation, a 2-year follow-up study was performed.Results: The reporting rate of ASC-US was 5.76% (2,304/40,000) in the study population. The detection rates of CIN 2 or above (CIN2+) and CIN 3 or above (CIN3+) in women with ASC-US were 7.28% and 1.75%, respectively. HPV 16 (39.53%), HPV 58 (17.83%), and HPV 52 (15.50%) were the three most prevalent HR-HPV genotypes among all women with ASC-US cytology. The five most common HR-HPV genotypes in CIN3+ lesions were HPV16, HPV58, HPV33, HPV31 and HPV18. Compared with the 15 HR-HPV testing, genotyping for a combination of HPV16/18/31/33/58 increased specificity significantly with virtually no loss of sensitivity for detecting CIN2+ and CIN3+ lesions, as well as significantly reduced colposcopy referral rate (23.15% vs 33.70%, p<0.01). In addition, in the 2-year follow-up period, women with infection of HPV16, 18, 31, 33 or 58 genotypes were the most likely population (92%, 23/25) to develop CIN2 lesion.Conclusion: Our results demonstrate that genotyping for a combination of HPV16/18/31/33/58 provides a more efficient and cost-effective model to risk-stratify women with ASC-US in the Chinese rural population. |
| Volume Number | 12 |
| PubMed Central reference number | PMC8040879 |
| Issue Number | 10 |
| PubMed reference number | 33854582 |
| Journal | Journal of Cancer [J Cancer] |
| e-ISSN | 18379664 |
| DOI | 10.7150/jca.55771 |
| Language | English |
| Publisher | Ivyspring International Publisher |
| Publisher Date | 2021-03-14 |
| Publisher Place | Sydney |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. © The author(s) |
| Subject Keyword | Human Papillomavirus (HPV) genotyping Atypical Squamous Cells of Undetermined Significance (ASC-US) cervical cancer screening Pap test cervical intraepithelial neoplasia |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
