A meta-analysis for comparison of partial nephrectomy vs. radical nephrectomy in patients with pT3a renal cell carcinoma.

Content Provider	Europe PMC
Author	Liu, Hui Kong, Qing-Fang Li, Jian Wu, Yu-Qing Pan, Ke-Hao Xu, Bin Wang, Ya-Li Chen, Ming
Copyright Year	2021
Abstract	BackgroundKidney cancer is the most common malignant tumor of the kidney in adults. However, in terms of the treatment for pT3a renal cell carcinoma (RCC), whether partial nephrectomy (PN) can be selected is still controversial. This study was conducted to compare the efficacy of PN and radical nephrectomy (RN) in treatment for patients with pT3a RCC.MethodsThe relative English databases including PubMed and EMBASE were searched for studies comparing PN and RN for pT3a RCC between 2010 and 2020. Stata 13.0 software was used to compare the cancer-specific survival (CSS), overall survival (OS), cancer-specific mortality (CSM), relapse-free survival (RFS), complications and positive surgical margin.ResultsNine articles were included with a total of 3,391 patients, of whom 2,113 received RN and 1,278 received PN. The results showed that there is no statistical difference in CSS, OS, CSM, RFS, complications and positive surgical margin between RN and PN. No heterogeneity was shown in study.ConclusionsThere were no differences in the CSS, OS, CSM, RFS, complications and positive surgical margin of the patients in RN and PN group. For pT3a RCC, RN did not provide a better survival benefit compared to PN. Considering PN can suppress the progression of tumor and reduce the risk of postoperative chronic renal insufficiency, we found PN is a good choice for pT3a RCC. However, further large-sample, studies are still needed in future.
ISSN	22234683
Journal	Translational Andrology and Urology
Volume Number	10
PubMed Central reference number	PMC8039616
Issue Number	3
PubMed reference number	33850752
e-ISSN	22234691
DOI	10.21037/tau-20-1262
Language	English
Publisher	AME Publishing Company
Publisher Date	2021-03-01
Access Restriction	Open
Rights License	Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0. 2021 Translational Andrology and Urology. All rights reserved.
Subject Keyword	Radical nephrectomy (RN) partial nephrectomy (PN) survival pT3a renal cell carcinoma (pT3a RCC) meta-analysis
Content Type	Text
Resource Type	Article
Subject	Urology Reproductive Medicine