Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy.

Content Provider	Europe PMC
Author	Yaman, Serkan Chintapula, Uday Rodriguez, Edgar Ramachandramoorthy, Harish Nguyen, Kytai T.
Abstract	Nanotechnology-based drug delivery platforms have been developed over the last two decades because of their favorable features in terms of improved drug bioavailability and stability. Despite recent advancement in nanotechnology platforms, this approach still falls short to meet the complexity of biological systems and diseases, such as avoiding systemic side effects, manipulating biological interactions and overcoming drug resistance, which hinders the therapeutic outcomes of the NP-based drug delivery systems. To address these issues, various strategies have been developed including the use of engineered cells and/or cell membrane-coated nanocarriers. Cell membrane receptor profiles and characteristics are vital in performing therapeutic functions, targeting, and homing of either engineered cells or cell membrane-coated nanocarriers to the sites of interest. In this context, we comprehensively discuss various cell- and cell membrane-based drug delivery approaches towards cancer therapy, the therapeutic potential of these strategies, and the limitations associated with engineered cells as drug carriers and cell membrane-associated drug nanocarriers. Finally, we review various cell types and cell membrane receptors for their potential in targeting, immunomodulation and overcoming drug resistance in cancer.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8011581&blobtype=pdf
Journal	Cancer Drug Resistance [Cancer Drug Resist]
Volume Number	3
DOI	10.20517/cdr.2020.55
PubMed Central reference number	PMC8011581
Issue Number	4
PubMed reference number	33796822
e-ISSN	2578532X
Language	English
Publisher	OAE Publishing Inc.
Publisher Date	2020-11-03
Access Restriction	Open
Rights License	© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. © The Author(s) 2020.
Subject Keyword	Cell membrane-based drug delivery cell-mediated drug delivery membrane receptors drug carriers cancer drug resistance nanoparticles
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Cancer Research