NDLI: Is lymphopenia different between SARS and COVID-19 patients?

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Is lymphopenia different between SARS and COVID-19 patients?

Content Provider	Europe PMC
Author	Yan, Shaomin Wu, Guang
Abstract	AbstractLymphopenia is commonly observed in SARS and COVID‐19 patients although the lymphocyte count is not always below 0.8 × 109/L in all the patients. It is suggested that lymphopenia serves as a useful predictor for prognosis in the patients. It is also hypothesized that lymphopenia is related to glucocorticoids and apoptosis. However, the ordering between lymphopenia and apoptosis appears different between SARS and COVID‐19 patients, ie, lymphopenia is prior to apoptosis in SARS patients whereas apoptosis is prior to lymphopenia in COVID‐19 patients. This paper attempts to figure out this contradiction through three players, lymphopenia, glucocorticoids, and apoptosis. Although the literature does not provide a solid explanation, the level of glucocorticoids could determine the ordering between lymphopenia and apoptosis because the administration of high doses of glucocorticoids could lead to lymphopenia whereas low doses of glucocorticoids could benefit patients. In the meantime, this paper raises several questions, which need to be answered in order to better understand the whole course of COVID‐19.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7995142&blobtype=pdf
Page Count	7
ISSN	08926638
Journal	The FASEB Journal [FASEB J]
Volume Number	35
DOI	10.1096/fj.202002512
PubMed Central reference number	PMC7995142
Issue Number	2
PubMed reference number	33495994
e-ISSN	15306860
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2021-02-01
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology
Subject Keyword	COVID‐19 lymphopenia glucocorticoids apoptosis SARS‐CoV SARS‐CoV‐2
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology Biochemistry Biotechnology

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