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Natural Orifice Specimen Extraction Surgery versus Conventional Laparoscopic-Assisted Resection in the Treatment of Colorectal Cancer: A Propensity-Score Matching Study.
| Content Provider | Europe PMC |
|---|---|
| Author | Tang, Qingchao Zhu, Yihao Xiong, Huan Sheng, Xiangzong Hu, Zhiqiao Hu, Hanqing Huang, Rui Zhang, Qian Yuan, Ziming Xie, Lei Gao, Zhifeng Wang, Yuliuming Wang, Guiyu Wang, Xishan |
| Copyright Year | 2021 |
| Abstract | BackgroundNatural orifice specimen extraction surgery (NOSES) has been successfully applied to the treatment of gastric, colorectal cancer (CRC). However, the development of NOSES is still in the exploratory stage, and there is still no strong evidence-based medical evidence.Patients and MethodsFrom January 2013 to June 2017, consecutive patients with colorectal cancer who underwent transluminal resection, anastomosis, and specimen extraction and those who underwent conventional laparoscopic resection were enrolled. Propensity score matching was used to align clinicopathological features between the two groups.ResultsA total of 372 patients were eventually included in this study, 186 in each group. According to perioperative information and postoperative follow-up in both groups, the NOSES group had less blood loss (P = 0.011), shorter time to recovery of gastrointestinal function (P < 0.001), shorter postoperative hospital stay (P = 0.037). The NOSES group had fewer postoperative analgesics (P < 0.001), lower postoperative pain scores (P < 0.001), and lower incidence of postoperative complications (P = 0.017). Compared with the LA (laparoscopic) group, the NOSES group had better physical function (P<0.05), role function (P<0.001), emotional function (P<0.001) and global health status than LA group, while symptoms such as pain (P<0.001), insomnia (P<0.001), constipation (P<0.001) and diarrhea (P<0.05) were less severe in the NOSES group. In addition, the NOSES group had higher body image scores. Overall survival (OS) and disease-free survival (DFS) were not significantly different between the two groups.ConclusionFor surgical treatment of colorectal cancer, NOSES has advantages in reducing postoperative pain, recovery of gastrointestinal function, postoperative quality of life, and improving patients’ satisfaction with abdominal wall aesthetics. There was no difference in long-term survival between NOSES and conventional laparoscopic surgery. |
| Page Count | 11 |
| Volume Number | 13 |
| PubMed Central reference number | PMC7955728 |
| PubMed reference number | 33727861 |
| Journal | Cancer Management and Research [Cancer Manag Res] |
| e-ISSN | 11791322 |
| DOI | 10.2147/CMAR.S291085 |
| Language | English |
| Publisher | Dove |
| Publisher Date | 2021-03-09 |
| Access Restriction | Open |
| Rights License | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). © 2021 Tang et al. |
| Subject Keyword | colorectal cancer laparoscopic surgery perioperative efficacy natural orifice specimen extraction survival |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
