NDLI: Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for 3 d: a randomised crossover trial.

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Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for 3 d: a randomised crossover trial.

Content Provider	Europe PMC
Author	Gaundal, Line Myhrstad, Mari C. W. Leder, Lena Byfuglien, Marte Gjeitung Gjøvaag, Terje Rud, Ida Retterstøl, Kjetil Holven, Kirsten B. Ulven, Stine M. Telle-Hansen, Vibeke H.
Copyright Year	2020
Abstract	Replacing intake of SFA with PUFA reduces serum cholesterol levels and CVD risk. The effect on glycaemic regulation is, however, less clear. The main objective of the present study was to investigate the short-term effect of replacing dietary SFA with PUFA on glycaemic regulation. Seventeen healthy, normal-weight participants completed a 25-d double-blind, randomised and controlled two-period crossover study. Participants were allocated to either interventions with PUFA products or SFA products (control) in a random order for three consecutive days, separated by a 1·5-week washout period between the intervention periods. Glucose, insulin and TAG were measured before and after an oral glucose tolerance test. In addition, fasting total cholesterol, NEFA and plasma total fatty acid profile were measured before and after the 3-d interventions. Fasting and postprandial glucose, insulin, and TAG levels and fasting levels of NEFA and plasma fatty acid profile did not differ between the groups. However, replacing dietary SFA with PUFA significantly reduced total cholesterol levels by 8 % after 3 d (P = 0·002). Replacing dietary SFA with PUFA for only 3 d has beneficial cardio-metabolic effects by reducing cholesterol levels in healthy individuals.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7944393&blobtype=pdf
Page Count	11
ISSN	00071145
Journal	The British Journal of Nutrition [Br J Nutr]
Volume Number	125
PubMed Central reference number	PMC7944393
Issue Number	8
PubMed reference number	32873354
e-ISSN	14752662
DOI	10.1017/s0007114520003402
Language	English
Publisher	Cambridge University Press
Publisher Date	2020-09-02
Publisher Place	Cambridge, UK
Access Restriction	Open
Rights License	This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. © The Author(s) 2020
Subject Keyword	Fatty acids Glycaemic regulation Cholesterol Healthy subjects Randomised crossover trials
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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