Prevalence of Short Stature and Growth Hormone Deficiency and Factors Associated With Short Stature After Fontan Surgery.

Content Provider	Europe PMC
Author	Matsumura, Shun Yana, Akiko Kuwata, Seiko Kurishima, Clara Saiki, Hirofumi Iwamoto, Yoichi Ishido, Hirotaka Masutani, Satoshi Senzaki, Hideaki
Copyright Year	2020
Abstract	Background: Fontan circulation is characterized by many features commonly observed in heart failure that may affect physical growth regardless of pituitary gland dysfunction status. The aims of the present study were to investigate the prevalence of short stature and growth hormone deficiency (GHD) and determine the factors associated with short stature after Fontan surgery.Methods and Results: On retrospective evaluation of 47 patients after Fontan surgery, a very high prevalence of short stature was observed (38.3%). In the short stature group, 5 patients were diagnosed with GHD (10.6% of patients after Fontan Surgery), which is much higher than the frequency of 1/10,000 in the general population. Central venous pressure (CVP) was significantly higher (14.6±4.5 vs. 12.2±1.9 mmHg, P<0.05) and the blood pressure and arterial oxygen saturation were significantly lower in the short stature group. Laboratory data also indicated volume retention and congestion in the short stature group. Mean change in stature from catheterization 1 year after Fontan surgery to the most recent visit was significantly lower in the short stature group (−1.1±1.1 SD vs. 0.0±0.8 SD, P<0.05) and significantly negatively correlated with CVP (r=−0.42, P<0.05).Conclusions: Volume retention and congestion, the prominent features of Fontan circulation, affect physical growth partly due to pituitary gland dysfunction, highlighting the need for the screening for and treatment of this condition after Fontan surgery.
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Journal	Circulation Reports [Circ Rep]
Volume Number	2
PubMed Central reference number	PMC7921366
Issue Number	4
PubMed reference number	33693236
e-ISSN	24340790
DOI	10.1253/circrep.cr-20-0009
Language	English
Publisher	The Japanese Circulation Society
Publisher Date	2020-03-14
Access Restriction	Open
Rights License	This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. Copyright © 2020, THE JAPANESE CIRCULATION SOCIETY
Subject Keyword	Fontan circulation Growth hormone deficiency Short stature
Content Type	Text
Resource Type	Article
Subject	Medicine