NDLI: Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers.

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Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers.

Content Provider	Europe PMC
Author	Abd El-Aziz, Yomna S. Spillane, Andrew J. Jansson, Patric J. Sahni, Sumit
Copyright Year	2021
Abstract	AbstractTriple-negative breast cancer (TNBC) is a group of breast cancers which neither express hormonal receptors nor human epidermal growth factor receptor. Hence, there is a lack of currently known targeted therapies and the only available line of systemic treatment option is chemotherapy or more recently immune therapy. However, in patients with relapsed disease after adjuvant or neoadjuvant therapy, resistance to chemotherapeutic agents has often developed, which results in poor treatment response. Multidrug resistance (MDR) has emerged as an important mechanism by which TNBCs mediate drug resistance and occurs primarily due to overexpression of ATP-binding cassette (ABC) transporter proteins such as P-glycoprotein (Pgp). Pgp overexpression had been linked to poor outcome, reduced survival rates and chemoresistance in patients. The aim of this mini-review is to provide a topical overview of the recent studies and to generate further interest in this critical research area, with the aim to develop an effective and safe approach for overcoming Pgp-mediated chemoresistance in TNBC.
Page Count	10
ISSN	01448463
Volume Number	41
PubMed Central reference number	PMC7909869
Issue Number	2
PubMed reference number	33543229
Journal	Bioscience Reports [Biosci. Rep]
e-ISSN	15734935
DOI	10.1042/BSR20204092
Language	English
Publisher	Portland Press Ltd.
Publisher Date	2021-02-01
Access Restriction	Open
Rights License	This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). © 2021 The Author(s).
Subject Keyword	breast cancers multidrug resistance p-glycoprotein triple negative breast cancer
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Biochemistry Biophysics

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