Multi-organ comparison of flow-based arterial spin labeling techniques: Spatially non-selective labeling for cerebral and renal perfusion imaging.

Content Provider	Europe PMC
Author	Franklin, Suzanne L. Bones, Isabell K. Harteveld, Anita A. Hirschler, Lydiane van Stralen, Marijn Qin, Qin de Boer, Anneloes Hoogduin, Johannes M. Bos, Clemens van Osch, Matthias J. P. Schmid, Sophie
Abstract	PurposeFlow‐based arterial spin labeling (ASL) techniques provide a transit‐time insensitive alternative to the more conventional spatially selective ASL techniques. However, it is not clear which flow‐based ASL technique performs best and also, how these techniques perform outside the brain (taking into account eg, flow‐dynamics, field‐inhomogeneity, and organ motion). In the current study we aimed to compare 4 flow‐based ASL techniques (ie, velocity selective ASL, acceleration selective ASL, multiple velocity selective saturation ASL, and velocity selective inversion prepared ASL [VSI‐ASL]) to the current spatially selective reference techniques in brain (ie, pseudo‐continuous ASL [pCASL]) and kidney (ie, pCASL and flow alternating inversion recovery [FAIR]).MethodsBrain (n = 5) and kidney (n = 6) scans were performed in healthy subjects at 3T. Perfusion‐weighted signal (PWS) maps were generated and ASL techniques were compared based on temporal SNR (tSNR), sensitivity to perfusion changes using a visual stimulus (brain) and robustness to respiratory motion by comparing scans acquired in paced‐breathing and free‐breathing (kidney).ResultsIn brain, all flow‐based ASL techniques showed similar tSNR as pCASL, but only VSI‐ASL showed similar sensitivity to perfusion changes. In kidney, all flow‐based ASL techniques had comparable tSNR, although all lower than FAIR. In addition, VSI‐ASL showed a sensitivity to B1‐inhomogeneity. All ASL techniques were relatively robust to respiratory motion.ConclusionIn both brain and kidney, flow‐based ASL techniques provide a planning‐free and transit‐time insensitive alternative to spatially selective ASL techniques. VSI‐ASL shows the most potential overall, showing similar performance as the golden standard pCASL in brain. However, in kidney, a reduction of B1‐sensitivity of VSI‐ASL is necessary to match the performance of FAIR.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7898485&blobtype=pdf
Page Count	15
ISSN	07403194
Journal	Magnetic Resonance in Medicine [Magn Reson Med]
Volume Number	85
DOI	10.1002/mrm.28603
PubMed Central reference number	PMC7898485
Issue Number	5
PubMed reference number	33251644
e-ISSN	15222594
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2020-11-30
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine
Subject Keyword	arterial spin labeling brain kidney perfusion imaging velocity selective ASL
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging