High-intensity interval training in the prehabilitation of cancer patients-a systematic review and meta-analysis.

Content Provider	Europe PMC
Author	Palma, Stefano Hasenoehrl, Timothy Jordakieva, Galateja Ramazanova, Dariga Crevenna, Richard
Abstract	PurposeTo evaluate the impact of high-intensity interval training (HIIT) on health-related outcome parameters in the prehabilitation of patients diagnosed with cancer.MethodsA systematic review and meta-analysis of comparative studies on HIIT in cancer prehabilitation conducted by screening standard databases from their inception to March 30, 2020. Outcomes of interest included cardiorespiratory fitness, feasibility, safety, clinical, and patient-reported outcomes.ResultsOf the 855 identified studies, 8 articles met the inclusion criteria (7 randomized, 1 non-randomized controlled trial) with a total of 896 patients. The study protocols were heterogeneous, but the methodological quality ranged from good to high according to PEDro scale. Meta-analysis revealed a significant improvement of peak oxygen consumption (VO2peak) achieved with HIIT compared to usual care. Furthermore, HIIT was feasible and safe, showing low risk of adverse events and positive effects on health-related outcomes in prehabilitative settings.ConclusionIn the phase of prehabilitation, HIIT has potential health benefits in patients diagnosed with cancer and is feasible and safe to perform. Nonetheless, larger randomized controlled trials focusing on long-term effects (such as cancer recurrence or survival rates) are missing, to underline the potential relevance of HIIT for cancer patients.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00520-020-05834-x.
ISSN	09414355
Journal	Supportive Care in Cancer
Volume Number	29
PubMed Central reference number	PMC7892520
Issue Number	4
PubMed reference number	33106975
e-ISSN	14337339
DOI	10.1007/s00520-020-05834-x
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2020-10-26
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020
Subject Keyword	Prehabilitation Preoperative care Cancer High-intensity interval training Meta-analysis Systematic review Exercise
Content Type	Text
Resource Type	Article
Subject	Rehabilitation Oncology (nursing) Oncology