Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents.

Content Provider	Europe PMC
Author	Bader, Ammar Bkhaitan, Majdi M. Abdalla, Ashraf N. Abdallah, Qasem M. A. Ali, Hamed I. Sabbah, Dima A. Albadawi, Ghadeer Abushaikha, Ghassan M.
Copyright Year	2021
Abstract	4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. The prepared compounds were afforded by reacting O-sulfonyl chloride podophyllotoxin with ammonia or aminoaryl/heteroaryl motif. Biological evaluation was performed in human breast cancer (MCF7), ovarian cancer (A2780), colon adenocarcinoma (HT29), and normal lung fibroblast (MRC5) cell lines. Compound 3 exhibited potent inhibitory activity and good selectivity margin. Compounds 2, 3, and 7 exerted apoptotic effect in MCF7 cells in a dose-dependent manner. The cytotoxicity of the verified compounds was inferior to that of podophyllotoxin.
ISSN	1741427X
Journal	Evidence-based Complementary and Alternative Medicine : Ecam
Volume Number	2021
PubMed Central reference number	PMC7857870
PubMed reference number	33574882
e-ISSN	17414288
DOI	10.1155/2021/6672807
Language	English
Publisher	Hindawi
Publisher Date	2021-01-25
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2021 Ammar Bader et al.
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine