What is the optimal lipid emulsion for preventing intestinal failure-associated liver disease following parenteral feeding in a rat model of short-bowel syndrome?

Content Provider	Europe PMC
Author	Machigashira, Seiro Kaji, Tatsuru Onishi, Shun Yano, Keisuke Harumatsu, Toshio Yamada, Koji Yamada, Waka Matsukubo, Makoto Muto, Mitsuru Ieiri, Satoshi
Abstract	PurposeComposite lipid emulsion (CLE) has been used for intestinal failure-associated liver disease (IFALD) to compensate for the disadvantages of soybean oil lipid emulsion (SOLE) or fish oil lipid emulsion (FOLE). However, the influence of its administration is unclear. We evaluated the effects of these emulsions on IFALD using a rat model of the short-bowel syndrome.MethodsWe performed jugular vein catheterization and 90% small bowel resection in Sprague–Dawley rats and divided them into four groups: control (C group), regular chow with intravenous administration of saline; and total parenteral nutrition co-infused with SOLE (SOLE group), CLE (CLE group) or FOLE (FOLE group).ResultsHistologically, obvious hepatic steatosis was observed in the SOLE and CLE groups but not the FOLE group. The liver injury grade of the steatosis and ballooning in the FOLE group was significantly better than in the SOLE group (p < 0.05). The TNF-α levels in the liver in the FOLE group were significantly lower than in the SOLE group (p < 0.05). Essential fatty acid deficiency (EFAD) was not observed in any group.ConclusionFish oil lipid emulsion attenuated hepatic steatosis without EFAD, while CLE induced moderate hepatic steatosis. The administration of CLE requires careful observation to prevent PN-induced hepatic steatosis.
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ISSN	01790358
Journal	Pediatric Surgery International [Pediatr Surg Int]
Volume Number	37
DOI	10.1007/s00383-020-04802-0
PubMed Central reference number	PMC7847428
Issue Number	2
PubMed reference number	33388967
e-ISSN	14379813
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2021-01-03
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Short-bowel syndrome Intestinal failure-associated liver disease Fish oil Composite lipid emulsion
Content Type	Text
Resource Type	Article
Subject	Surgery Pediatrics, Perinatology and Child Health