NDLI: Lamin B2 promotes the progression of triple negative breast cancer via mediating cell proliferation and apoptosis.

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Lamin B2 promotes the progression of triple negative breast cancer via mediating cell proliferation and apoptosis.

Content Provider	Europe PMC
Author	Zhao, Cui-Cui Chen, Jing Zhang, Li-Ying Liu, Hong Zhang, Chuan-Gui Liu, Yan
Copyright Year	2021
Abstract	AbstractTriple negative breast cancer (TNBC) is a more common type of breast cancer with high distant metastasis and poor prognosis. The potential role of lamins in cancer progression has been widely revealed. However, the function of lamin B2 (LMNB2) in TNBC progression is still unclear. The present study aimed to investigate the role of LMNB2 in TNBC. The cancer genome atlas (TCGA) database analysis and immunohistochemistry (IHC) were performed to examine LMNB2 expression levels. LMNB2 short hairpin RNA plasmid or lentivirus was used to deplete the expression of LMNB2 in human TNBC cell lines including MDA-MB-468 and MDA-MB-231. Alterations in cell proliferation and apoptosis in vitro and the nude mouse tumorigenicity assay in vivo were subsequently analyzed. The human TNBC tissues shown high expression of LMNB2 according to the bioinformation analysis and IHC assays. LMNB2 expression was correlated with the clinical pathological features of TNBC patients, including pTNM stage and lymph node metastasis. Through in vitro and in vivo assays, we confirmed LMNB2 depletion suppressed the proliferation and induced the apoptosis of TNBC cells, and inhibited tumor growth of TNBC cells in mice, with the decrease in Ki67 expression or the increase in caspase-3 expression. In conclusion, LMNB2 may promote TNBC progression and could serve as a potential therapeutic target for TNBC treatment.
Page Count	11
ISSN	01448463
Volume Number	41
PubMed Central reference number	PMC7846963
Issue Number	1
PubMed reference number	33416073
Journal	Bioscience Reports [Biosci. Rep]
e-ISSN	15734935
DOI	10.1042/BSR20203874
Language	English
Publisher	Portland Press Ltd.
Publisher Date	2021-01-01
Access Restriction	Open
Rights License	This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). © 2021 The Author(s).
Subject Keyword	Apoptosis Breast cancer Lamin B2 (LMNB2) Proliferation Target Triple negative breast cancer (TNBC)
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Biochemistry Biophysics

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