Electrocardiographic Changes in Children with Multisystem Inflammation Associated with COVID-19: Associated with Coronavirus Disease 2019.

Content Provider	Europe PMC
Author	Regan, William O’Byrne, Laura Stewart, Kirsty Miller, Owen Pushparajah, Kuberan Theocharis, Paraskevi Wong, James Rosenthal, Eric
Copyright Year	2020
Abstract	ObjectiveTo analyze findings and trends on serial electrocardiograms (ECGs) in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease taken during the course of illness and at follow-up.Study designWe included all children presenting with MIS-C at a single center with 3 or more ECGs taken during the course of their illness. We measured ECG intervals (PR, QRSd, and QTc) and amplitudes (R-, S-, and T-waves) on each ECG and documented any arrhythmias and ST-segment changes.ResultsA majority of children (n = 42, 67%) showed ECG changes. The most common findings were low QRS amplitudes and transient T-wave inversion. ST changes were uncommon and included ST-segment elevation consistent with pericarditis in 1 child and acute coronary ischemia in 1 child. Arrhythmias were seen in 13 children (21%) but were benign with the exception of 1 child who was compromised by an atrial tachycardia requiring support with extracorporeal membrane oxygenation. No children were found to have high-grade atrioventricular block.ConclusionsMIS-C is associated with electrocardiographic changes over the course of the illness, with low amplitude ECGs on presentation, followed by transient T-wave inversion, particularly in the precordial leads. There was a low prevalence of ST-segment changes and tachyarrhythmias.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7836928&blobtype=pdf
ISSN	00223476
Journal	The Journal of Pediatrics [J Pediatr]
Volume Number	234
DOI	10.1016/j.jpeds.2020.12.033
PubMed Central reference number	PMC7836928
PubMed reference number	33358846
e-ISSN	10976833
Language	English
Publisher	Published by Elsevier Inc.
Publisher Date	2021-01-13
Access Restriction	Open
Rights License	Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Crown Copyright © 2020 Published by Elsevier Inc. All rights reserved.
Subject Keyword	coronavirus SARS-CoV-2 arrhythmias MIS-C PIMS pediatric COVID-19, Coronavirus disease 2019 ECG, Electrocardiogram ECMO, Extracorporeal membrane oxygenation ICU, Intensive care unit MIS-C, Multisystem inflammatory syndrome in children PICU, Pediatric intensive care unit SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TWI, T-wave inversion
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health