Association between interleukin 6 polymorphisms (rs1800796, rs1800795, rs2069837, rs17147230, and rs1800797) and hepatocellular carcinoma susceptibility: a meta-analysis.

Content Provider	Europe PMC
Author	Aleagha, Omid Emami Oltulu, Pembe Sadeghi, Masoud
Copyright Year	2020
Abstract	Aim of the studyWe reported the association between interleukin 6 polymorphisms (rs1800796, rs1800795, rs2069837, rs17147230, and rs1800797) and hepatocellular carcinoma (HCC) susceptibility in a meta-analysis.Material and methodsThe studies were retrieved by searching the search terms in Scopus, PubMed, Web of Science, and Cochrane Library databases until June 2020. The analyses were done by RevMan 5.3 software using odds ratios (ORs) and 95% confidence intervals (CIs) and the analysis of publication bias and sensitivity analyses were performed by CMA 2.0 software.ResultsSearching through the databases, 316 records were retrieved and finally 13 studies were analyzed in the present meta-analysis. For the rs1800797 polymorphism, there was an elevated risk of AA genotype (OR = 2.68, p = 0.03) in HCC patients compared to healthy controls. Also, there was an elevated risk of AA (OR = 3.06, p = 0.04) and GA (OR = 2.61, p = 0.005) genotypes in HCC patients compared to liver cirrhosis patients. For rs2069837 polymorphism, there was an elevated risk of GG genotype (OR = 2.25, p = 0.01) in HCC patients compared to healthy controls. For rs17147230, T allele (OR = 1.31, p = 0.03) and TT genotype (OR = 1.83, p = 0.02) had elevated risks in HCC patients compared to healthy controls.ConclusionsThe present meta-analysis confirmed that there was an elevated risk of the AA and GA genotypes of rs1800797 polymorphism and the GG genotype of rs2069837, and the T allele and TT genotype of rs17147230 in HCC.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7816640&blobtype=pdf
ISSN	23921099
Journal	Clinical and Experimental Hepatology [Clin Exp Hepatol]
Volume Number	6
DOI	10.5114/ceh.2020.102171
PubMed Central reference number	PMC7816640
Issue Number	4
PubMed reference number	33511285
e-ISSN	24498238
Language	English
Publisher	Termedia Publishing House
Publisher Date	2020-12-30
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. Copyright: © 2020 Clinical and Experimental Hepatology
Subject Keyword	polymorphism interleukin 6 hepatocellular carcinoma hepatitis cirrhosis
Content Type	Text
Resource Type	Article
Subject	Hepatology