Systemic Inflammatory Biomarkers, Especially Fibrinogen to Albumin Ratio, Predict Prognosis in Patients with Pancreatic Cancer.

Content Provider	Europe PMC
Author	Fang, Lin Yan, Fei-Hu Liu, Chao Chen, Jing Wang, Dan Zhang, Chun-Hui Lou, Chang-Jie Lian, Jie Yao, Yang Wang, Bo-Jun Li, Rui-Yang Han, Shu-Ling Bai, Yi-Bing Yang, Jia-Ni Li, Zhi-Wei Zhang, Yan-Qiao
Copyright Year	2021
Abstract	PurposeSystemic inflammatory response is a critical factor that promotes the initiation and metastasis of malignancies including pancreatic cancer (PC). This study was designed to determine and compare the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and fibrinogen-to-albumin ratio (FAR) in resectable PC and locally advanced or metastatic PC.Materials and MethodsThree hundred fifty-three patients with resectable PC and 807 patients with locally advanced or metastatic PC were recruited in this study. These patients were classified into a training set (n=758) and a validation set (n=402). Kaplan-Meier survival plots and Cox proportional hazards regression models were used to analyze prognosis.ResultsOverall survival (OS) was significantly better for patients with resectable PC with low preoperative PLR (p=0.048) and MLR (p=0.027). Low FAR, MLR, NLR (p < 0.001), and PLR (p=0.003) were significantly associated with decreased risk of death for locally advanced or metastatic PC patients. FAR (hazard ratio [HR], 1.522; 95% confidential interval [CI], 1.261 to 1.837; p < 0.001) and MLR (HR, 1.248; 95% CI, 1.017 to 1.532; p=0.034) were independent prognostic factors for locally advanced or metastatic PC.ConclusionThe prognostic roles of FAR, MLR, NLR, and PLR in resectable PC and locally advanced or metastatic PC were different. FAR showed the most prognostic power in locally advanced or metastatic PC. Low FAR was positively correlated with OS in locally advanced or metastatic PC, which could be used to predict the prognosis.
ISSN	15982998
Journal	Cancer Research and Treatment : Official Journal of Korean Cancer Association
Volume Number	53
PubMed Central reference number	PMC7811998
Issue Number	1
PubMed reference number	32854494
e-ISSN	20059256
DOI	10.4143/crt.2020.330
Language	English
Publisher	Korean Cancer Association
Publisher Date	2020-08-24
Access Restriction	Open
Rights License	This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2021 by the Korean Cancer Association
Subject Keyword	Pancreatic neoplasms Systemic inflammatory markers Fibrinogen-to-albumin ratio Prognosis Survival
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology