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Association of lymphocyte count and incidence of maternal fever in epidural analgesia-involved labor.
| Content Provider | Europe PMC |
|---|---|
| Author | Chai, Jing Jia, Lijie Cao, Huimin Zhang, Xiaoyu Xu, Zifeng |
| Copyright Year | 2020 |
| Abstract | BackgroundEvidence showed that the use of epidural analgesia increased the risk of maternal fever during labor, and the potential mechanisms involved inflammation. Lymphocyte played a role in the inflammatory responses, and lymphopenia predicted adverse outcomes for patients. The aim of this study was to investigate whether lymphocyte count was associated with the incidence of intrapartum fever in nulliparous women undergoing vaginal delivery.MethodsIn this retrospective cohort study, electronic medical record data at the International Peace Maternity and Child Health Hospital (IPMCH, Shanghai, China) between 2012 and 2017 were extracted. The primary outcome of this study was baseline lymphocyte count in febrile and afebrile parturients who received labor epidural analgesia. Other confounding factors associated with the development of intrapartum fever were analyzed using multivariable logistic regression.ResultsThe final study population consisted of 36,562 parturients, of whom 18,952 (51.8%) received labor epidural analgesia. Labor epidural analgesia was associated with an increased risk of maternal fever [relative risk: 4.55; 95% confidence interval (CI): 4.16–4.98; P<0.001]. Among the parturients who received epidural analgesia, both baseline lymphocyte count and lymphocyte percentage were lower in the febrile patients than those in the afebrile patients (P<0.001; P=0.015). The lower (<1.1×109/L) baseline lymphocyte was associated with a higher risk of maternal fever (adjusted odds ratio: 1.30, 95% CI: 1.14–1.48; P<0.001).ConclusionsOur results suggested that lower lymphocyte baseline indicated an increased risk of maternal fever during epidural analgesia-involved labor. Further studies are needed to confirm the findings and determine the potential mechanisms. |
| ISSN | 23055839 |
| Volume Number | 8 |
| PubMed Central reference number | PMC7791247 |
| Issue Number | 23 |
| PubMed reference number | 33437783 |
| Journal | Annals of Translational Medicine [Ann Transl Med] |
| e-ISSN | 23055847 |
| DOI | 10.21037/atm-20-1724 |
| Language | English |
| Publisher | AME Publishing Company |
| Publisher Date | 2020-12-01 |
| Access Restriction | Open |
| Rights License | Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0. 2020 Annals of Translational Medicine. All rights reserved. |
| Subject Keyword | Epidural analgesia labor lymphocyte maternal fever |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
