NDLI: Epigenome-wide association scan identifies methylation sites associated with HIV infection.

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Epigenome-wide association scan identifies methylation sites associated with HIV infection.

Content Provider	Europe PMC
Author	Shu, Chang Jaffe, Andrew E Sabunciyan, Sarven Ji, Hongkai Astemborski, Jacquie Sun, Jing Bakulski, Kelly M Mehta, Shruti H Kirk, Gregory D Maher, Brion S
Copyright Year	2020
Abstract	Aim: To investigate the role of epigenetics in HIV pathophysiology. Materials & methods: We conducted an epigenome-wide association scan on HIV infection status among people who inject drugs in the AIDS Linked to the IntraVenous Experience study with primary (n = 397) and validation samples (n = 390). DNA methylation from blood was measured by the Illumina EPIC BeadChip. We controlled for cell type heterogeneity by HIV status. Results: HIV infection status was associated (p < 10-8) with DNA methylation at 49 CpG sites. Sites were enriched in response to virus, interferon signaling pathway, etc. Among these sites, discovery and validation t-statistics were highly correlated (r = 0.96). Conclusion: In a cohort of people who inject drugs, HIV status was associated with differential DNA methylation at biologically meaningful sites.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7788472&blobtype=pdf
Page Count	11
ISSN	17501911
Volume Number	12
DOI	10.2217/epi-2020-0123
PubMed Central reference number	PMC7788472
Issue Number	21
PubMed reference number	33232214
Journal	Epigenomics
e-ISSN	1750192X
Language	English
Publisher	Future Medicine Ltd
Publisher Date	2020-11-24
Publisher Place	London, UK
Access Restriction	Open
Rights License	© 2020 Future Medicine Ltd
Subject Keyword	DNA methylation epigenetics epigenome-wide association HIV people who inject drugs
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research

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