Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age.

Content Provider	Europe PMC
Author	Arjaans, Sanne Haarman, Meindina G Roofthooft, Marcus T R Fries, Marian W F Kooi, Elisabeth M W Bos, Arend F Berger, Rolf M F
Copyright Year	2021
Abstract	ObjectiveTo determine the survival and evolution of pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD) in extremely premature born infants beyond 36 weeks postmenstrual age (PMA).DesignA single-centre retrospective cohort study from a university hospital.PatientsExtremely preterm (gestational age <30 weeks and/or birth weight <1000 g) infants, born between 2012 and 2017, in the University Medical Center Groningen with confirmed PH at/beyond 36 weeks PMA.Main outcome measuresSurvival, mortality rate and PH resolution. Patient characteristics, treatment, presence and evolution of PH were collected from patient charts.ResultsTwenty-eight infants were included. All had BPD, while 23 (82%) had severe BPD and 11 infants (39%) died. Survival rates at 1, 3 and 7 months from 36 weeks PMA were 89%, 70% and 58%, respectively. In 16 of the 17 surviving infants, PH resolved over time, with a resolution rate at 1 and 2 years corrected age of 47% and 79%, respectively. At 2.5 years corrected age, the resolution rate was 94%.ConclusionsThese extremely preterm born infants with PH-BPD had a survival rate of 58% at 6 months corrected age. Suprasystemic pulmonary artery pressure was associated with poor outcome. In the current study, infants surviving beyond the corrected age of 6 months showed excellent survival and resolution of PH in almost all cases. Prospective follow-up studies should investigate whether resolution of PH in these infants can be improved by multi-modal therapies, including respiratory, nutritional and cardiovascular treatments.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7788204&blobtype=pdf
ISSN	13592998
Journal	Archives of Disease in Childhood. Fetal and Neonatal Edition [Arch Dis Child Fetal Neonatal Ed]
Volume Number	106
DOI	10.1136/archdischild-2019-318531
PubMed Central reference number	PMC7788204
Issue Number	1
PubMed reference number	32571832
e-ISSN	14682052
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2020-06-22
Publisher Place	BMA House, Tavistock Square, London, WC1H 9JR
Access Restriction	Open
Rights License	This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
Subject Keyword	neonatology cardiology
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Obstetrics and Gynecology