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Development of SARS-CoV-2 vaccines: challenges, risks, and the way forward.
| Content Provider | Europe PMC |
|---|---|
| Author | Vashishtha, Vipin M. Kumar, Puneet |
| Copyright Year | 2020 |
| Abstract | The COVID-19 pandemic mandates the development of a safe and effective Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) vaccine. This review analyzes the complexities, challenges, and other vital issues associated with the development of the SARS-CoV-2 vaccine. A brief review of the immune responses (innate, antibody, and T-cell) to SARS-CoV-2, including immune targets, correlates of protection, and duration of immunity is presented. Approaches to vaccine development including different vaccine platforms, critical attributes of novel vaccine candidates, the status of the ongoing clinical trials, and the ways to speed up vaccine development are also reviewed. Despite a historical average success rate of only 6%, and a usual gestation period of 10–12 years for the development of a new vaccine, the world is on the verge of developing COVID-19 vaccines in an extraordinary short time span. |
| Page Count | 15 |
| ISSN | 21645515 |
| Journal | Human Vaccines & Immunotherapeutics |
| Volume Number | 17 |
| PubMed Central reference number | PMC7754925 |
| Issue Number | 6 |
| PubMed reference number | 33270478 |
| e-ISSN | 2164554X |
| DOI | 10.1080/21645515.2020.1845524 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2020-12-03 |
| Access Restriction | Open |
| Rights License | © 2020 Taylor & Francis Group, LLC |
| Subject Keyword | SARS-CoV-2 vaccines vaccine development immune responses neutralizing antibodies antibody-dependent enhancement |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Pharmacology Immunology |
