Navigating the COVID-19 pandemic: Initial impacts and responses of the Organ Procurement and Transplantation Network in the United States.

Content Provider	Europe PMC
Author	Goff, Rebecca R. Wilk, Amber R. Toll, Alice E. McBride, Maureen A. Klassen, David K.
Copyright Year	2021
Abstract	COVID-19 has been sweeping the globe, hitting the United States particularly hard with a state of emergency declared on March 13, 2020. Transplant hospitals have taken various precautions to protect patients from potential exposure. OPTN donor, candidate, and transplant data were analyzed from January 5, 2020 to September 5, 2020. The number of new waiting list registrations decreased, with the Northeast seeing over a 50% decrease from the week of 3/8 versus the week of 4/5. The national transplant system saw near cessation of living donor transplantation (–90%) from the week of 3/8 to the week of 4/5. Similarly, deceased donor kidney transplant volume dropped from 367 to 202 (–45%), and other organs saw similar decreases: lung (–70%), heart (–43%), and liver (–37%). Deceased donors recovered dropped from 260 to 163 (–45%) from 3/8 compared to 4/5, including a 67% decrease for lungs recovered. The magnitude of this decrease varied by geographic area, with the largest percent change (–67%) in the Northeast. Despite the pandemic, discard rates across organ has remained stable. Although the COVID-19 pandemic continues to evolve, OPTN data show recent evidence of stabilization, an indication that an early recovery of the number of living and deceased donors and transplants has ensued.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7754561&blobtype=pdf
ISSN	16006135
Journal	American Journal of Transplantation [Am J Transplant]
Volume Number	21
DOI	10.1111/ajt.16411
PubMed Central reference number	PMC7754561
Issue Number	6
PubMed reference number	33244847
e-ISSN	16006143
Language	English
Publisher	American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc.
Publisher Date	2020-12-16
Access Restriction	Open
Rights License	Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Copyright © 2021 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.
Subject Keyword	donors and donation: deceased donors and donation: living ethics and public policy infection and infectious agents - viral infectious disease organ procurement organ procurement and allocation Organ Procurement and Transplantation Network (OPTN) organ transplantation in general CDC, Centers for Disease Control COD, causes of death COVID-19, coronavirus disease 2019 CPRA, Calculated Panel Reactive Antibodies DSA, donation service area HHS, Department of Health and Human Services HRSA, Health Resources and Services Administration LAS, lung allocation score MELD, model for end-stage liver disease MERS, Middle East respiratory syndrome coronavirus NM, nautical mile OPO, Organ Procurement Organization OPTN, Organ Procurement and Transplantation Network PELD, pediatric end-stage liver disease SARS, severe acute respiratory syndrome SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 SRTR, Scientific Registry of Transplant Recipients UNOS, United Network for Organ Sharing US, United States
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Transplantation Pharmacology (medical)