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Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review).

Content Provider	Europe PMC
Author	Zhu, Gui-Xian Gao, Dian Shao, Zhao-Zhao Chen, Li Ding, Wen-Jie Yu, Qiong-Fang
Copyright Year	2020
Abstract	Colorectal cancer (CRC) is the third most common malignant tumor in humans. Chemotherapy is used for the treatment of CRC. However, the effect of chemotherapy remains unsatisfactory due to drug resistance. Growing evidence has shown that the presence of highly metastatic tumor stem cells, regulation of non-coding RNAs and the tumor microenvironment contributes to drug resistance mechanisms in CRC. Wnt/β-catenin signaling mediates the chemoresistance of CRC in these three aspects. Therefore, the present study analyzed the abundant evidence of the contribution of Wnt/β-catenin signaling to the development of drug resistance in CRC and discussed its possible role in improving the chemosensitivity of CRC, which may provide guidelines for its clinical treatment.
ISSN	17912997
Journal	Molecular Medicine Reports
Volume Number	23
PubMed Central reference number	PMC7723170
Issue Number	2
PubMed reference number	33300082
e-ISSN	17913004
DOI	10.3892/mmr.2020.11744
Language	English
Publisher	D.A. Spandidos
Publisher Date	2020-12-10
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Zhu et al.
Subject Keyword	colorectal cancer Wnt/β-catenin signaling drug resistance tumor stem cells non-coding RNAs tumor microenvironment
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Biochemistry Cancer Research Molecular Medicine Oncology

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