New insight into dental epithelial stem cells: Identification, regulation, and function in tooth homeostasis and repair.

Content Provider	Europe PMC
Author	Gan, Lu Liu, Ying Cui, Di-Xin Pan, Yue Wan, Mian
Copyright Year	2020
Abstract	Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisors grow continuously due to the presence of DESCs that generate enamel-producing ameloblasts and other supporting dental epithelial lineages. The ready accessibility of mouse DESCs and wide availability of related transgenic mouse lines make mouse incisors an excellent model to examine the identity and heterogeneity of dental epithelial stem/progenitor cells; explore the regulatory mechanisms underlying enamel formation; and help answer the open question regarding the therapeutic development of enamel engineering. In the present review, we update the current understanding about the identification of DESCs in mouse incisors and summarize the regulatory mechanisms of enamel formation driven by DESCs. The roles of DESCs during homeostasis and repair are also discussed, which should improve our knowledge regarding enamel tissue engineering.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7705464&blobtype=pdf
Journal	World Journal of Stem Cells [World J Stem Cells]
Volume Number	12
DOI	10.4252/wjsc.v12.i11.1327
PubMed Central reference number	PMC7705464
Issue Number	11
PubMed reference number	33312401
e-ISSN	19480210
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2020-11-01
Access Restriction	Open
Rights License	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Subject Keyword	Dental epithelial stem cells Tissue engineering Label-retaining cells Lineage tracing Single-cell sequencing
Content Type	Text
Resource Type	Article
Subject	Cell Biology Genetics Molecular Biology Genetics (clinical) Histology