NDLI: An Expanded Surface-Enhanced Raman Scattering Tags Library by Combinatorial Encapsulation of Reporter Molecules in Metal Nanoshells.

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An Expanded Surface-Enhanced Raman Scattering Tags Library by Combinatorial Encapsulation of Reporter Molecules in Metal Nanoshells.

Content Provider	Europe PMC
Author	Rodal-Cedeira, Sergio Vázquez-Arias, Alba Bodelón, Gustavo Skorikov, Alexander Núñez-Sánchez, Sara Laporta, Andrea Polavarapu, Lakshminarayana Bals, Sara Liz-Marzán, Luis M. Pérez-Juste, Jorge Pastoriza-Santos, Isabel
Copyright Year	2020
Abstract	Raman-encodedgold nanoparticles (NPs) have been widely employedas photostable multifunctional probes for sensing, bioimaging, multiplexdiagnostics, and surface-enhanced Raman scattering (SERS)-guided tumortherapy. We report a strategy toward obtaining a particularly largelibrary of Au nanocapsules encoded with Raman codes defined by thecombination of different thiol-free Raman reporters, encapsulatedat defined molar ratios. The fabrication of SERS tags with tailoredsize and predefined codes is based on the in situ incorporation of Raman reporter molecules inside Au nanocapsulesduring their formation via galvanic replacement coupledto seeded growth on Ag NPs. The hole-free closed-shell structure ofthe nanocapsules is confirmed by electron tomography. The unusuallywide encoding possibilities of the obtained SERS tags are investigatedby means of either wavenumber-based encoding or Raman frequency combinedwith signal intensity, leading to an outstanding performance as exemplifiedby 26 and 54 different codes, respectively. We additionally demonstratethat encoded nanocapsules can be readily bioconjugated with antibodiesfor applications such as SERS-based targeted cell imaging and phenotyping.
ISSN	19360851
Journal	ACS Nano
Volume Number	14
PubMed Central reference number	PMC7690041
Issue Number	11
PubMed reference number	32869970
e-ISSN	1936086X
DOI	10.1021/acsnano.0c04368
Language	English
Publisher	AmericanChemical Society
Publisher Date	2020-10-05
Access Restriction	Open
Rights License	This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Subject Keyword	plasmonic nanocapsules SERS tags SERS library combinatorial encapsulation cell imaging
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Physics and Astronomy Engineering Materials Science

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