NDLI: Genetic Variants and Haplotypes in <i>OPG</i> Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study.

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Genetic Variants and Haplotypes in OPG Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study.

Content Provider	Europe PMC
Author	Pérez-Hernández, Nonanzit Posadas-Sánchez, Rosalinda Vargas-Alarcón, Gilberto Cazarín-Santos, Benny Giovanni Miranda-Duarte, Antonio Rodríguez-Pérez, José Manuel
Copyright Year	2020
Abstract	Basic and clinical research have demonstrated that osteoprotegerin (OPG) plays an important role in the development and progression of cardiovascular diseases. The aim of this study was to evaluate the association of four polymorphic sites (rs2073618, rs3134069, rs3134070, and rs3102735) of OPG gene with premature coronary artery disease (pCAD), and with cardiometabolic parameters. The polymorphisms were genotyped using 5′ exonuclease TaqMan genotyping assays with real-time PCR in 1098 individuals with pCAD and 1041 healthy controls. rs2073618 polymorphism was associated with a high risk of developing pCAD according to different inheritance models: additive (p = 0.001; odds ratio [OR] = 1.283), dominant (p = 0.006; OR = 1.383), recessive (p = 0.011; OR = 1.423), and codominant 2 (p = 0.001; OR = 1.646). The four polymorphisms were associated with different cardiovascular risk factors in individuals with pCAD and controls. Our results suggest that OPG rs2073618 polymorphism is associated with an increased risk of pCAD. In addition, two haplotypes were associated with pCAD, one increasing the risk (CACT) and another one as protective (GACC).
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7687050&blobtype=pdf
Page Count	10
ISSN	10445498
Volume Number	39
DOI	10.1089/dna.2020.5949
PubMed Central reference number	PMC7687050
Issue Number	11
PubMed reference number	32955941
Journal	DNA and Cell Biology [DNA Cell Biol]
e-ISSN	15577430
Language	English
Publisher	Mary Ann Liebert, Inc., publishers
Publisher Date	2020-09-21
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2020, Mary Ann Liebert, Inc., publishers
Subject Keyword	premature coronary artery disease osteoprotegerin vascular calcification polymorphisms haplotypes genetic association
Content Type	Text
Resource Type	Article
Subject	Cell Biology Genetics Medicine Molecular Biology

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