NDLI: Dealing with pre-existing chronic neutropenia in cancer patients-considerations and consequences in the clinical praxis.

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Dealing with pre-existing chronic neutropenia in cancer patients-considerations and consequences in the clinical praxis.

Content Provider	Europe PMC
Author	Thinggaard, Anna-Birgitte Liposits, Gabor Fristrup, Niels
Copyright Year	2020
Abstract	Chronic neutropenia is a rare but important challenge with substantial clinical implications for patients receiving antineoplastic treatment. Treatment-induced neutropenia is a well-known adverse event during chemotherapy and some targeted treatments. Guidelines for administering chemotherapy are rather strict to protect the patient from severe and life-threatening complications. Consequently, patients with chronic neutropenia may receive suboptimal antineoplastic treatment. Autoimmune neutropenia or chronic idiopathic neutropenia (CIN) may affect the antineoplastic treatment by causing delayed drug delivery, dose reductions and early discontinuation of treatment. CIN is characterised by the onset in late childhood or adulthood, affects mostly women, is clinically benign and has rare spontaneous remission. Here, we elucidate the challenges related to chronic neutropenia when administering chemotherapy through two clinical cases. Guidelines may need to be revised in order to optimise the treatment of patients with asymptomatic chronic neutropenia, thus personalising the medical decisions for each patient.
Journal	ecancermedicalscience
Volume Number	14
PubMed Central reference number	PMC7652427
PubMed reference number	33209122
e-ISSN	17546605
DOI	10.3332/ecancer.2020.1131
Language	English
Publisher	Cancer Intelligence
Publisher Date	2020-10-29
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © the authors; licensee ecancermedicalscience.
Subject Keyword	chronic neutropenia autoimmune neutropenia chronic idiopathic neutropenia chemotherapy targeted therapy monoclonal antibodies
Content Type	Text
Resource Type	Article
Subject	Oncology Cancer Research

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