NDLI: Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review).

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Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review).

Content Provider	Europe PMC
Author	Liu, Ting Shi, Fuli Ying, Ying Chen, Qiongfeng Tang, Zhimin Lin, Hui
Copyright Year	2020
Abstract	Abnormal menstruation may result in several pathological alterations and gynaecological diseases, including endometriosis, menstrual pain and miscarriage. However, the pathogenesis of menstruation remains unclear due to the limited number of animal models available to study the menstrual cycle. In recent years, an effective, reproducible, and highly adaptive mouse model to study menstruation has been developed. In this model, progesterone and oestrogen were administered in cycles following the removal of ovaries. Subsequently, endometrial decidualisation was induced using sesame oil, followed by withdrawal of progesterone administration. Vaginal bleeding in mice is similar to that in humans. Therefore, the use of mice as a model organism to study the mechanism of menstruation and gynaecological diseases may prove to be an important breakthrough. The present review is focussed ond the development and applications of a mouse model of menstruation. Furthermore, various studies have been described to improve this model and the research findings that may aid in the treatment of menstrual disorders in women are presented.
ISSN	17912997
Journal	Molecular Medicine Reports
Volume Number	22
PubMed Central reference number	PMC7646730
Issue Number	6
PubMed reference number	33174022
e-ISSN	17913004
DOI	10.3892/mmr.2020.11567
Language	English
Publisher	D.A. Spandidos
Publisher Date	2020-10-07
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Liu et al.
Subject Keyword	endometrium gynaecology menstruation model NF-κB shedding repair
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Biochemistry Cancer Research Molecular Medicine Oncology

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