NDLI: Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia.

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Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia.

Content Provider	Europe PMC
Author	Maqsood, Anum Akram, Salman Akram, Faisal
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2020
Abstract	Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by recurrent multiple motor and vocal tics that last for at least one year and follow a waxing and waning course. A fundamental step in the pathophysiology of TS is the hyperactivity of dopaminergic system leading to increased dopamine release in the cortical-basal ganglia-thalamo-cortical (CBGTC) circuits, thereby providing the rationale for treatment with dopamine receptor, in particular D2, antagonists. Although antipsychotics have shown considerable efficacy against tics in most patients, there have been cases of paradoxical onset of tics in individuals without history, and relapse or exacerbation of tics in individuals with a history of tic disorders upon initiation of antipsychotics. Here we report a case of an individual with intellectual disability, attention deficit hyperactivity disorder (ADHD), and schizophrenia, who experienced a relapse of TS symptoms after initiation of chlorpromazine therapy.
Journal	Cureus
Volume Number	12
DOI	10.7759/cureus.10732
PubMed Central reference number	PMC7599051
Issue Number	9
PubMed reference number	33145137
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2020-09-30
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	tourette syndrome chlorpromazine attention deficit hyperactivity disorder schizophrenia
Content Type	Text
Resource Type	Case study
Subject	Medicine

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