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An adult case of invasive pneumococcal disease due to serotype 12F-specific polysaccharide antibody failure following a 23-valent polysaccharide vaccination.
| Content Provider | Europe PMC |
|---|---|
| Author | Tanaka, Yasuhiro Yamamoto, Kazuko Fukuda, Yuichi Umemura, Asuka Yoshida, Masataka Ideguchi, Shuhei Ashizawa, Nobuyuki Hirayama, Tatsuro Tashiro, Masato Takazono, Takahiro Imamura, Yoshifumi Miyazaki, Taiga Izumikawa, Koichi Yanagihara, Katsunori Chang, Bin Mukae, Hiroshi |
| Copyright Year | 2020 |
| Abstract | A 68-year-old Japanese man was admitted to our hospital for an acute febrile illness with shivering and impaired consciousness. He was a previous smoker and had a history of chronic obstructive pulmonary disease, for which he inhaled steroid with a long-acting bronchodilator. He had received a 23-valent pneumococcal polysaccharide vaccination 2 years previously. He was intubated and placed on a ventilator in intensive care unit because of acute respiratory failure and hypercapnia. Streptococcus pneumoniae was grown from his blood, sputum, and urine cultures, and he was diagnosed with invasive pneumococcal disease with acute renal failure. He was treated with intravenous beta-lactam and macrolide with continuous hemodiafiltration and was discharged 3 months later. The pneumococcus was identified as serotype 12F, and his serotype-specific IgG and opsonophagocytic index against serotype 12F indicating a lack of protection from IPD among PPV23 serotypes. This case highlights that some individuals may have a serotype-specific polysaccharide antibody failure that makes them susceptible to serotype 12F invasive pneumococcal disease. This case also illustrates the need for serotype-specific IgG and opsonophagocytic index titre cut-offs for each specific pneumococcal serotype in available vaccines to understand the vaccination protection for individual patients better. |
| Page Count | 3 |
| Journal | Emerging Microbes & Infections |
| Volume Number | 9 |
| PubMed Central reference number | PMC7594767 |
| Issue Number | 1 |
| PubMed reference number | 32990189 |
| e-ISSN | 22221751 |
| DOI | 10.1080/22221751.2020.1830716 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2020-12-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd |
| Subject Keyword | Pneumococcal vaccine Streptococcus pneumoniae infection Streptococcus pneumoniae serotype 12 F invasive pneumococcal disease opsonophagocytosis assay |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology Infectious Diseases Virology Drug Discovery Microbiology Epidemiology Parasitology |
