Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study.

Content Provider	Europe PMC
Author	Koopman‐Verhoeff, Maria Elisabeth Mulder, Rosa H. Saletin, Jared M. Reiss, Irwin van der Horst, Gijsbertus T.J. Felix, Janine F. Carskadon, Mary A. Tiemeier, Henning Cecil, Charlotte A.M.
Abstract	BackgroundDNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population.MethodsThis cross‐sectional study included 465 10‐year‐old children (51.3% female) from the Generation R Study. Genome‐wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self‐report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11‐year‐old children to calculate sleep duration and midpoint sleep. Weighted gene co‐expression network analysis was used to identify highly comethylated DNAm ‘modules’, which were tested for associations with sleep and mental health outcomes.ResultsWe identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT – a key regulator of Tau proteins in the brain involved in neuronal function – as well as genes previously implicated in sleep duration. Follow‐up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood–brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health.ConclusionsWe identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7586967&blobtype=pdf
Page Count	9
ISSN	00219630
Journal	Journal of Child Psychology and Psychiatry, and Allied Disciplines [J Child Psychol Psychiatry]
Volume Number	61
DOI	10.1111/jcpp.13252
PubMed Central reference number	PMC7586967
Issue Number	10
PubMed reference number	32361995
e-ISSN	14697610
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2020-05-03
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2020 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.
Subject Keyword	DNA methylation sleep psychopathology accelerometer epigenetics epigenome
Content Type	Text
Resource Type	Article
Subject	Developmental and Educational Psychology Psychiatry and Mental Health Pediatrics, Perinatology and Child Health