NDLI: Facile H/D Exchange at (Hetero)Aromatic Hydrocarbons Catalyzed by a Stable Trans-Dihydride N-Heterocyclic Carbene (NHC) Iron Complex.

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Facile H/D Exchange at (Hetero)Aromatic Hydrocarbons Catalyzed by a Stable Trans-Dihydride N-Heterocyclic Carbene (NHC) Iron Complex.

Content Provider	Europe PMC
Author	Garhwal, Subhash Kaushansky, Alexander Fridman, Natalia Shimon, Linda J. W. Ruiter, Graham de
Copyright Year	2020
Abstract	Earth-abundantmetal pincer complexes have played an importantrole in homogeneous catalysis during the last ten years. Yet, despiteintense research efforts, the synthesis of iron PCcarbeneP pincer complexes has so far remained elusive. Here we report thesynthesis of the first PCNHCP functionalized iron complex[(PCNHCP)FeCl2] (1) and the reactivityof the corresponding trans-dihydride iron(II) dinitrogencomplex [(PCNHCP)Fe(H)2N2)] (2). Complex 2 is stable under an atmosphere ofN2 and is highly active for hydrogen isotope exchange at(hetero)aromatic hydrocarbons under mild conditions (50 °C, N2). With benzene-d6 as the deuteriumsource, easily reducible functional groups such as esters and amidesare well tolerated, contributing to the overall wide substrate scope(e.g., halides, ethers, and amines). DFT studies suggest a complexassisted σ-bond metathesis pathway for C(sp2)–Hbond activation, which is further discussed in this study.
ISSN	00027863
Volume Number	142
PubMed Central reference number	PMC7586338
Issue Number	40
PubMed reference number	32902969
Journal	Journal of the American Chemical Society [J. Am. Chem. Soc]
e-ISSN	15205126
DOI	10.1021/jacs.0c07689
Language	English
Publisher	American ChemicalSociety
Publisher Date	2020-09-22
Access Restriction	Open
Rights License	This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Content Type	Text
Resource Type	Article
Subject	Chemistry Colloid and Surface Chemistry Biochemistry Catalysis

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