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A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering.
| Content Provider | Europe PMC |
|---|---|
| Author | Shuai, Cijun Yang, Youwen Feng, Pei Peng, Shuping Guo, Wang Min, Anjie Gao, Chengde |
| Copyright Year | 2018 |
| Abstract | It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment. In this work, a novel combined process of additive manufacturing (AM) and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid) (GO/PLLA) scaffolds with multiscale porous structure. Specially, AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns. And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface. The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores. Moreover, the scaffolds exhibited surprising bioactivity after chemical etching, which was ascribed to the formed polar groups on scaffolds surfaces. Furthermore, GO improved the mechanical strength of the scaffolds. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7582010&blobtype=pdf |
| ISSN | 24247723 |
| Journal | International Journal of Bioprinting [Int J Bioprint] |
| Volume Number | 4 |
| PubMed Central reference number | PMC7582010 |
| Issue Number | 2 |
| PubMed reference number | 33102914 |
| e-ISSN | 24248002 |
| DOI | 10.18063/ijb.v4i2.133 |
| Language | English |
| Publisher | Whioce Publishing Pte. Ltd. |
| Publisher Date | 2018-03-31 |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Attribution-NonCommercial 4.0 International 4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. Copyright: © 2018 Shuai C et al. |
| Subject Keyword | multi-scale pores scaffolds additive manufacturing chemical etching PLLA |
| Content Type | Text |
| Resource Type | Article |
| Subject | Industrial and Manufacturing Engineering Materials Science Biotechnology |
