Loading...
Please wait, while we are loading the content...
Similar Documents
Comparison of dexmedetomidine with midazolam for dental surgery: A systematic review and meta-analysis.
| Content Provider | Europe PMC |
|---|---|
| Author | Zhang, Yibo Li, Chao Shi, Jingjing Gong, Yanming Zeng, Tao Lin, Min Zhang, Xi |
| Editor | Bhatt., Girish Chandra |
| Copyright Year | 2020 |
| Abstract | AbstractIntroduction:Dexmedetomidine and midazolam have become important approaches for the sedation of dental surgery. However, the comparison of these 2 drugs for the sedation of dental surgery has not been well established. We conduct a systematic review and meta-analysis to evaluate the efficacy of dexmedetomidine versus midazolam for dental surgery.Methods:PubMed, Embase, and the Cochrane Central Register of Controlled Trials are searched. Randomized controlled trials (RCTs) assessing the influence of dexmedetomidine versus midazolam on dental surgery are included. Two investigators independently have searched articles, extracted data, and assessed the quality of included studies. Meta-analysis is performed using the random-effect model.Results:Five RCTs and 420 patients are included in the meta-analysis. Compared with midazolam intervention for dental surgery, dexmedetomidine intervention has similar lowest SpO2, lowest heart rate and lowest systolic blood pressure, duration of surgery, and total volume of local anesthetic, but is associated with stable and reduced lowest diastolic blood pressure.Conclusions:Similar benefits of dexmedetomidine and midazolam intervention are observed for the sedation of dental surgery in terms of SpO2, heart rate, systolic blood pressure, and the volume of local anesthetic, but dexmedetomidine may result in more stable diastolic blood pressure. |
| ISSN | 00257974 |
| Journal | Medicine |
| Volume Number | 99 |
| PubMed Central reference number | PMC7581133 |
| Issue Number | 43 |
| PubMed reference number | 33120732 |
| e-ISSN | 15365964 |
| DOI | 10.1097/md.0000000000022288 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2020-10-01 |
| Publisher Place | Hagerstown, MD |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. |
| Subject Keyword | dental surgery dexmedetomidine meta-analysis midazolam randomized controlled trials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
