NDLI: EGFR C797S as a Resistance Mechanism of Lazertinib in Non-small Cell Lung Cancer with EGFR T790M Mutation.

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EGFR C797S as a Resistance Mechanism of Lazertinib in Non-small Cell Lung Cancer with EGFR T790M Mutation.

Content Provider	Europe PMC
Author	Park, Sehhoon Ku, Bo Mi Jung, Hyun Ae Sun, Jong-Mu Ahn, Jin Seok Lee, Se-Hoon Park, Keunchil Ahn, Myung-Ju
Copyright Year	2020
Abstract	The non-small cell lung cancer with activating epidermal growth factor receptor (EGFR) mutation eventually acquires resistant to either first or second-generation EGFR tyrosine kinase inhibitor (TKI). As the following option, targeting EGFR T790M with third-generation EGFR TKI is now established as a standard treatment option. In this study, we are reporting the first case of resistance mechanism to the novel third-generation EGFR TKI, lazertinib, which showed promising clinical efficacy in phase 1-2 study. The patients showed resistance to the treatment by acquiring the additional EGFR C797S mutation in cis which is also confirmed from the patient-derived cell lines.
ISSN	15982998
Journal	Cancer Research and Treatment : Official Journal of Korean Cancer Association
Volume Number	52
PubMed Central reference number	PMC7577810
Issue Number	4
PubMed reference number	32599977
e-ISSN	20059256
DOI	10.4143/crt.2020.278
Language	English
Publisher	Korean Cancer Association
Publisher Date	2020-06-22
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2020 by the Korean Cancer Association
Subject Keyword	Non-small cell lung cancer Lazertinib Third-generation EGFR tyrosine kinase inhibitor ErbB receptors
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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