Diagnostic and prognostic value of HABP2 as a novel biomarker for endometrial cancer.

Content Provider	Europe PMC
Author	Jiang, Ying Li, Jinfeng Sang, Cuiqin Cao, Guangming Wang, Shuzhen
Copyright Year	2020
Abstract	BackgroundEndometrial cancer is the fifth most common malignant disorder in women, with its incidence increasing. A biomarker with diagnostic and prognostic value remains to be found. The HABP2 protein, or Factor VII-activating protease, encodes a hyaluronic acid-binding protein.MethodsPatient data including clinical characteristics and RNAseq information of HABP2 was obtained from The Cancer Genome Atlas (TCGA), and analyzed by R statistic packages. A total of 370 women with endometrial cancer were enrolled in the study. To study the diagnostic value of HABP2 in patients with endometrial cancer, receiver operating characteristic (ROC) curves were plotted by the pROC package. To study the prognostic value of HABP2 in patients with endometrial cancer, the survival package in R was used and the Cox model was established.ResultsHABP2 expression was lower in endometrial cancer compared with normal endometrial tissues. HABP2 showed moderate diagnostic value for endometrial cancer, with HBP2 expression associated with vital status, histologic grade, and residual tumor. HABP2 was an independent prognostic factor, with low HABP2 expression indicating a better overall survival.ConclusionsHABP2 has diagnostic and prognostic value and maybe a novel biomarker for endometrial cancer.
ISSN	23055839
Volume Number	8
PubMed Central reference number	PMC7576057
Issue Number	18
PubMed reference number	33241013
Journal	Annals of Translational Medicine [Ann Transl Med]
e-ISSN	23055847
DOI	10.21037/atm-20-5744
Language	English
Publisher	AME Publishing Company
Publisher Date	2020-09-01
Access Restriction	Open
Rights License	Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0. 2020 Annals of Translational Medicine. All rights reserved.
Subject Keyword	Endometrial cancer HABP2 diagnosis prognosis biomarker
Content Type	Text
Resource Type	Article
Subject	Medicine