Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children.

Content Provider	Europe PMC
Author	Park, Jeong Ha Son, Young Don Kim, Yeni Han, Doug Hyun
Copyright Year	2020
Abstract	Objective We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to attention-deficit hyperactivity disorder (ADHD) symptoms.Methods Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes.Results Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers.Conclusion We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD.
ISSN	17383684
Journal	Psychiatry Investigation
Volume Number	17
PubMed Central reference number	PMC7538244
Issue Number	9
PubMed reference number	32894926
e-ISSN	19763026
DOI	10.30773/pi.2020.0132
Language	English
Publisher	Korean Neuropsychiatric Association
Publisher Date	2020-09-09
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2020 Korean Neuropsychiatric Association
Subject Keyword	Attention-deficit hyperactivity disorder Dorsal attention network Default mode network Catechol-O-methyltransferase
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health