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Association between Atrial Fibrillation and Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease.
| Content Provider | Europe PMC |
|---|---|
| Author | Kang, Min Kyu Park, Jung Gil Kim, Min Cheol |
| Copyright Year | 2020 |
| Abstract | PurposeNon-alcoholic fatty liver disease (NAFLD) is independently associated with the development of atrial fibrillation (AF). However, the association of AF with advanced liver fibrosis, which is related to all-cause, cardiovascular, and liver-related mortality, has not been established in NAFLD patients. We aimed to investigate the association between AF and advanced liver fibrosis in NAFLD patients.Materials and MethodsOut of 53704 adults who participated in the health check-up program, 6293 subjects aged 35 years and older were diagnosed as NAFLD using ultrasound. The stage of liver fibrosis was assessed based on the newly adjusted NAFLD fibrosis score (NFS) and Fibrosis-4 (Fib-4) Index, which were used to determine the low and high cut-off values (COVs).ResultsOf 6293 patients with NAFLD, 59 (0.9%) were diagnosed with AF. Patients with AF were older (52.0 vs. 64.6 years, p<0.001), had higher body mass index (25.2 vs. 26.6 kg/m2, p<0.001), and had bigger waist circumference (84.0 vs. 89.9 cm, p<0.001) than those without AF. In NAFLD patients, AF was independently associated with advanced liver fibrosis, assessed using both COVs of NFS [low-COV group: final adjusted odds ratios (aORs)=2.85, p=0.004; high-COV group: ORs=12.29, p<0.001). AF was independently associated with advanced liver fibrosis, assessed using both COVs of Fib-4 (low-COV group: aORs=2.49, p<0.001; high-COV group: aORs=3.84, p=0.016).ConclusionAF is independently associated with advanced liver fibrosis in patients with NAFLD. |
| ISSN | 05135796 |
| Volume Number | 61 |
| PubMed Central reference number | PMC7515788 |
| Issue Number | 10 |
| PubMed reference number | 32975060 |
| Journal | Yonsei Medical Journal [Yonsei Med. J] |
| e-ISSN | 19762437 |
| DOI | 10.3349/ymj.2020.61.10.860 |
| Language | English |
| Publisher | Yonsei University College of Medicine |
| Publisher Date | 2020-10-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2020 |
| Subject Keyword | Atrial fibrillation fibrosis metabolic syndrome non-alcoholic fatty liver disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
