Tying up loose ends: the N-degron and C-degron pathways of protein degradation.

Content Provider	Europe PMC
Author	Timms, Richard T. Koren, Itay
Copyright Year	2020
Abstract	Selective protein degradation by the ubiquitin-proteasome system (UPS) is thought to be governed primarily by the recognition of specific motifs — degrons — present in substrate proteins. The ends of proteins — the N- and C-termini – have unique properties, and an important subset of protein–protein interactions involve the recognition of free termini. The first degrons to be discovered were located at the extreme N-terminus of proteins, a finding which initiated the study of the N-degron (formerly N-end rule) pathways, but only in the last few years has it emerged that a diverse set of C-degron pathways target analogous degron motifs located at the extreme C-terminus of proteins. In this minireview we summarise the N-degron and C-degron pathways currently known to operate in human cells, focussing primarily on those that have been discovered in recent years. In each case we describe the cellular machinery responsible for terminal degron recognition, and then consider some of the functional roles of terminal degron pathways. Altogether, a broad spectrum of E3 ubiquitin ligases mediate the recognition of a diverse array of terminal degron motifs; these degradative pathways have the potential to influence a wide variety of cellular functions.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7458402&blobtype=pdf
ISSN	03005127
Journal	Biochemical Society Transactions [Biochem Soc Trans]
Volume Number	48
PubMed Central reference number	PMC7458402
Issue Number	4
PubMed reference number	32627813
e-ISSN	14708752
DOI	10.1042/bst20191094
Language	English
Publisher	Portland Press Ltd.
Publisher Date	2020-08-01
Access Restriction	Open
Rights License	This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). Open access for this article was enabled by the participation of University of Cambridge in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. © 2020 The Author(s)
Subject Keyword	C-degron pathways degron E3 ubiquitin ligases N-degron pathways protein termini ubiquitin proteasome system
Content Type	Text
Resource Type	Article
Subject	Biochemistry