NDLI: Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma.

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Development of an Immune-Related Risk Signature in Patients with Bladder Urothelial Carcinoma.

Content Provider	Europe PMC
Author	Jiang, Yaofei Wang, Yibing Li, Cong Zou, Zhenhong Liang, Bo
Copyright Year	2020
Abstract	With recent advances in immunooncology and tumor microenvironment, the treatment landscape of bladder urothelial carcinoma has been changing dramatically. We aim to construct an immune gene-related signature which can predict BLCA patients' overall survival. Transcriptomic data of BLCA patients was downloaded from The Cancer Genome Atlas database, and immune-related genes were downloaded from the Immunology Database and Analysis Portal database. Prognostic immune-related genes were identified. We then constructed and validated an immune gene-related signature. Tumor-related transcription factors were downloaded from the Cistrome database, and a network between them and prognostic immune-related genes was generated. Cox's proportional hazards model and the Kaplan–Meier survival analysis were performed to assess our signature's prognostic ability. Relationship between the signature and patients' clinicopathologic features was then explored to validate its clinical value. We further downloaded concentration of six types of immune cells from the Tumor Immune Estimation Resource database to explore immune-related potential mechanisms of the signature.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2020
PubMed Central reference number	PMC7455840
PubMed reference number	32884943
e-ISSN	23146141
DOI	10.1155/2020/5848493
Language	English
Publisher	Hindawi
Publisher Date	2020-08-20
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2020 Yaofei Jiang et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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