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Neurophysiological insights in dystonia and its response to deep brain stimulation treatment.
| Content Provider | Europe PMC |
|---|---|
| Author | Tisch, Stephen Limousin, Patricia |
| Abstract | Dystonia is a movement disorder characterised by involuntary muscle contractions resulting in abnormal movements, postures and tremor. The pathophysiology of dystonia is not fully understood but loss of neuronal inhibition, excessive sensorimotor plasticity and defective sensory processing are thought to contribute to network dysfunction underlying the disorder. Neurophysiology studies have been important in furthering our understanding of dystonia and have provided insights into the mechanism of effective dystonia treatment with pallidal deep brain stimulation. In this article we review neurophysiology studies in dystonia and its treatment with Deep Brain Stimulation, including Transcranial magnetic stimulation studies, studies of reflexes and sensory processing, and oscillatory activity recordings including local field potentials, micro-recordings, EEG and evoked potentials. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7413898&blobtype=pdf |
| ISSN | 00144819 |
| Journal | Experimental Brain Research [Exp Brain Res] |
| Volume Number | 238 |
| DOI | 10.1007/s00221-020-05833-8 |
| PubMed Central reference number | PMC7413898 |
| Issue Number | 7 |
| Issue Number | 7-8 |
| PubMed reference number | 32638036 |
| e-ISSN | 14321106 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2020-07-07 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020 |
| Subject Keyword | Dystonia Neurophysiology Gpi DBS |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
