Development of clinical prediction rule for diagnosis of autistic spectrum disorder in children.

Content Provider	Europe PMC
Author	Lerthattasilp, Tiraya Tanprasertkul, Chamnan Chunsuwan, Issarapa
Copyright Year	2020
Abstract	PurposeThis study aims to develop a clinical prediction rule for the diagnosis of autistic spectrum disorder (ASD) in children.Design/methodology/approachThis population-based study was carried out in children aged 2 to 5 years who were suspected of having ASD. Data regarding demographics, risk factors, histories taken from caregivers and clinical observation of ASD symptoms were recorded before specialists assessed patients using standardized diagnostic tools. The predictors were analyzed by multivariate logistic regression analysis and developed into a predictive model.FindingsAn ASD diagnosis was rendered in 74.8 per cent of 139 participants. The clinical prediction rule consisted of five predictors, namely, delayed speech for their age, history of rarely making eye contact or looking at faces, history of not showing off toys or favorite things, not following clinician’s eye direction and low frequency of social interaction with the clinician or the caregiver. At four or more predictors, sensitivity was 100 per cent for predicting a diagnosis of ASD, with a positive likelihood ratio of 16.62.Originality/valueThis practical clinical prediction rule would help general practitioners to initially diagnose ASD in routine clinical practice.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7370955&blobtype=pdf
Page Count	10
ISSN	20367457
Journal	Mental Illness [Ment Illn]
Volume Number	12
PubMed Central reference number	PMC7370955
Issue Number	1
PubMed reference number	32742626
e-ISSN	20367465
DOI	10.1108/mij-01-2020-0001
Language	English
Publisher	Emerald Publishing Limited
Publisher Date	2020-03-20
Access Restriction	Open
Rights License	Published by Emerald Publishing Limited. This article is published under the Creative Commons Attribution (CC BY 4.0) licence. Anyone may reproduce, distribute, translate and create derivative works of this article (for both commercial and non-commercial purposes), subject to full attribution to the original publication and authors. The full terms of this licence may be seen at: http://creativecommons.org/licences/by/4.0/legalcode © Tiraya Lerthattasilp, Chamnan Tanprasertkul and Issarapa Chunsuwan.
Subject Keyword	Autistic spectrum disorder Autism Autistic Prediction Diagnosis
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health