Loading...
Please wait, while we are loading the content...
Similar Documents
Organophosphorus compounds and oximes: a critical review.
| Content Provider | Europe PMC |
|---|---|
| Author | Worek, Franz Thiermann, Horst Wille, Timo |
| Abstract | Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more than six decades. Established oximes, i.e. pralidoxime, obidoxime, TMB-4, HI-6 and MMB-4, are of insufficient effectiveness in some poisonings and often cover only a limited spectrum of the different nerve agents and pesticides. Moreover, the value of oximes in human OP pesticide poisoning is still disputed. Long-lasting research efforts resulted in the preparation of countless experimental oximes, and more recently non-oxime reactivators, intended to replace or supplement the established and licensed oximes. The progress of this development is slow and none of the novel compounds appears to be suitable for transfer into advanced development or into clinical use. This situation calls for a critical analysis of the value of oximes as mainstay of treatment as well as the potential and limitations of established and novel reactivators. Requirements for a straightforward identification of superior reactivators and their development to licensed drugs need to be addressed as well as options for interim solutions as a chance to improve the therapy of OP poisoning in a foreseeable time frame. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7367912&blobtype=pdf |
| ISSN | 03405761 |
| Journal | Archives of Toxicology [Arch Toxicol] |
| Volume Number | 94 |
| DOI | 10.1007/s00204-020-02797-0 |
| PubMed Central reference number | PMC7367912 |
| Issue Number | 7 |
| PubMed reference number | 32506210 |
| e-ISSN | 14320738 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2020-06-06 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020 |
| Subject Keyword | Organophosphorus compounds Nerve agents Pesticides Acetylcholinesterase Oximes Reactivation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology |
