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PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/β‑catenin signaling pathway.
| Content Provider | Europe PMC |
|---|---|
| Author | Ma, Dede Hou, Li Xia, Hechun Li, Hailiang Fan, Heng Jia, Xiaoxiong Niu, Zhanfeng |
| Copyright Year | 2020 |
| Abstract | Glioblastoma is a highly malignant tumor that contains stem-like cells known as glioma stem cells (GSCs), which lare associated with an increased risk of glioma occurrence, recurrence and poor prognosis. Circadian clock gene, period circadian clock 2 (PER2) expression has been revealed to be inhibited in various types of cancer. However, the precise role and potential mechanisms of PER2 in GSCs remains unclear. The present study demonstrated that PER2 mRNA and protein expression was downregulated in GSCs compared with non-stem glioma cells, which indicated that PER2 could be involved in the malignant process of glioma. Furthermore, functional studies revealed that PER2 overexpression could induce GSC arrest at the G0/G1 phase and suppress their proliferation, stemness and invasion ability in vitro and in vivo. Subsequently, the Wnt/β-catenin signaling pathway was identified as the target of PER2 in GSCs. These results indicated that PER2 plays a critical role in regulating the stemness of GSCs and provides a novel therapeutic target to overcome the effects of GSCs. |
| ISSN | 1021335X |
| Journal | Oncology Reports |
| Volume Number | 44 |
| PubMed Central reference number | PMC7336516 |
| Issue Number | 2 |
| PubMed reference number | 32468039 |
| e-ISSN | 17912431 |
| DOI | 10.3892/or.2020.7624 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2020-05-27 |
| Access Restriction | Open |
| Rights License | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Copyright: © Ma et al. |
| Subject Keyword | PER2 glioma stem cells stemness Wnt/β-catenin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
