NDLI: The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease.

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The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease.

Content Provider	Europe PMC
Author	Kim, Hyung Jin Jung, YunJae
Copyright Year	2020
Abstract	Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate that eosinophils are not only associated with the pathogenesis of a wide range of diseases, but also contribute to the maintenance of homeostatic responses in previously underappreciated diverse tissues, such as the gastrointestinal (GI) tract and adipose tissue. In this review, we describe biological characteristics of eosinophils, as their developmental properties, permissive proliferation and survival, degranulation activity, and migration properties enable them to distribute to both homeostatic and inflamed tissues. We describe pathologic aspects of eosinophils with a role in asthma and in various GI diseases, including eosinophilic GI disorders, inflammatory bowel disease, and radiation-induced enteropathy. Finally, we discuss the beneficial role of eosinophils, which contribute to the resolution of pathogenic conditions and to the modulation of homeostatic biologic responses.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7327148&blobtype=pdf
ISSN	15982629
Journal	Immune Network [Immune Netw]
Volume Number	20
DOI	10.4110/in.2020.20.e24
PubMed Central reference number	PMC7327148
Issue Number	3
PubMed reference number	32655972
e-ISSN	20926685
Language	English
Publisher	The Korean Association of Immunologists
Publisher Date	2020-06-23
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2020. The Korean Association of Immunologists
Subject Keyword	Eosinophils Eosinophil granule proteins Hypersensitivity Eosinophilic gastrointestinal disorders Homeostasis
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy Immunology

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