NDLI: Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties.

Please wait, while we are loading the content...

Challenges to optimizing RNA nanostructures for large scale production and controlled therapeutic properties.

Content Provider	Europe PMC
Author	Chandler, Morgan Panigaj, Martin Rolband, Lewis A Afonin, Kirill A
Copyright Year	2020
Abstract	Nucleic acids have been utilized to construct an expansive collection of nanoarchitectures varying in design, physicochemical properties, cellular processing and biomedical applications. However, the broader therapeutic adaptation of nucleic acid nanoassemblies in general, and RNA-based nanoparticles in particular, have faced several challenges in moving towards (pre)clinical settings. For one, the large-batch synthesis of nucleic acids is still under development, with multi-stranded and chemically modified assemblies requiring greater production capacity while maintaining consistent medical-grade outputs. Furthermore, the unknown immunostimulation by these nanomaterials poses additional challenges, necessary to be overcome for optimizing future development of clinically approved RNA nanoparticles.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7304434&blobtype=pdf
Page Count	10
ISSN	17435889
DOI	10.2217/nnm-2020-0034
PubMed Central reference number	PMC7304434
Issue Number	13
PubMed reference number	32452262
Journal	Nanomedicine [Nanomedicine (Lond)]
e-ISSN	17486963
Language	English
Publisher	Future Medicine Ltd
Publisher Date	2020-05-26
Publisher Place	London, UK
Access Restriction	Open
Rights License	© 2020 Future Medicine Ltd
Subject Keyword	immune stimulation nanoparticles NANPs RNA nanoparticles RNA nanotechnology self-assembly TNAs
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Development Bioengineering Materials Science Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in