Loading...
Please wait, while we are loading the content...
Similar Documents
Complications of surgery for gastro-entero-pancreatic neuroendocrine neoplasias.
| Content Provider | Europe PMC |
|---|---|
| Author | Albers, Max B. Almquist, Martin Bergenfelz, Anders Nordenström, Erik |
| Abstract | PurposeSurgery is recommended for most patients with gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NENs). Rates of complications and perioperative mortality have been reported in few mostly retrospective single-center series, but there has been no detailed analysis on risk factors for perioperative complications and mortality to date.MethodsData of patients with GEP-NENs operated between January 2015 and September 2018 were retrieved from EUROCRINE©, a European online endocrine surgical quality registry, and analyzed regarding rate and risk factors of surgical complications. Risk factors were assessed by logistic regression.ResultsSome 376 patients (211 female, 167 male; age median 63, range 15–89 years) were included. Most NENs were located in the small intestine (SI) (n = 132) or pancreas (n = 111), the rest in the stomach (n = 34), duodenum (n = 30), appendix (n = 30), colon, and rectum (n = 22), or with unknown primary (n = 15). Of the tumors, 320 (85.1%) were well or moderately differentiated, and 147 (39.1%) of the patients had distant metastases at the time of operation. Severe complications (Dindo-Clavien ≥ 3) occurred in 56 (14.9%) patients, and 4 (1.1%) patients died perioperatively. Severe complications were more frequent in surgery for duodenopancreatic NENs (n = 31; 22.0%) compared with SI-NENs (n = 15; 11.4%) (p = 0.014), in patients with lymph node metastases operated with curative aim of surgery (n = 24; 21.4%) versus non-metastasized tumors or palliative surgery (n = 32; 12.1%) (p = 0.020), and in functioning tumors (n = 20; 23.0%) versus non-functioning tumors (n = 30; 13.5%) (p = 0.042). Complication rates were not significantly associated with tumor stage or grade.ConclusionsSevere complications are frequent in GEP-NEN surgery. Besides duodenopancreatic tumor location, curative resection of nodal metastases and functioning tumors are risk factors for complications. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7239819&blobtype=pdf |
| ISSN | 14352443 |
| Journal | Langenbeck's Archives of Surgery [Langenbecks Arch Surg] |
| Volume Number | 405 |
| DOI | 10.1007/s00423-020-01869-0 |
| PubMed Central reference number | PMC7239819 |
| Issue Number | 2 |
| PubMed reference number | 32291468 |
| e-ISSN | 14352451 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2020-03-01 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020 |
| Subject Keyword | Neuroendocrine neoplasia Perioperative complications Surgery Gastro-entero-pancreatic system Small intestine Pancreas |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery |
